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The technetium-labeled agents are lost slowly from the myocardium, with comparable clearance from normal and ischemic tissue.Since Tc99m-labeled tracers are essentially fixed in the cells, separate injections are required for the rest and the stress portions of the examination.These agents are very different in behavior compared with Thallous chloride.

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Optimally, the rest and stress exams are performed on separate days.

Same-day studies use as little as 8-10 m Ci for the first dose and up to 45 m Ci for the second.

The second injection should contain 2.5 to 3 times the resting dose.

The doses are adjusted for the weight of the patient.

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