By the third century AD, Palmyra was a prosperous regional center reaching the apex of its power in the 260s, when Palmyrene King Odaenathus defeated Persian Emperor Shapur I.
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Archaeological finds date back to the Neolithic period, and the city was first documented in the early second millennium BC.
Palmyra changed hands on a number of occasions between different empires before becoming a subject of the Roman Empire in the first century AD.
The city grew wealthy from trade caravans; the Palmyrenes were renowned merchants who established colonies along the Silk Road and operated throughout the Roman Empire.