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However, it is clear that this process involves a gene regulatory network in which a Y chromosome-linked master gene, named SRY (sex determining region of the Y), plays a crucial role (Sinclair et al., 1990).

SRY induces the undifferentiated embryonic gonad to develop as a testis (Koopman et al., 1991).

The results and hypotheses concerning this polled intersex syndrome (PIS) are then presented, firstly with respect to the transcriptional regulatory effects of the PIS mutation, and secondly regarding the role of the main ovarian-differentiating factor in this PIS locus, the FOXL2 gene. Karger AG, Basel Published online: November 16, 2011 Issue release date: February 2012 Number of Print Pages: 13 Number of Figures: 7 Number of Tables: 0 ISSN: 1661-5425 (Print) e ISSN: 1661-5433 (Online) For additional information: Copyright: All rights reserved.

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IT is generally considered that the Y chromosome is necessary for the development of the mammalian testis and the consequent male phenotype.

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